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Z16.1

Z16.1Resistance to beta lactam antibiotics

Non-billable headerICD-10-CM

Z16.1 is a non-billable header ICD-10-CM code for resistance to beta lactam antibiotics. It cannot be billed on its own: choose one of the more specific child codes below.

Other codes that can never be billed with Z16.1

These codes carry an Excludes1 note pointing at Z16.1. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading Z16.1 alone.

  • Z16.3Resistance to other antimicrobial drugs

Risk adjustment

Z16.1 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code to one of these instead Z16.1

5 child codes. Green means billable.

Related codes at this level

Codes that share Z16. If Z16.1 is not quite right, the correct code is usually one of these.

Questions about Z16.1

Is Z16.1 a billable ICD-10-CM code?
No. Z16.1 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does Z16.1 sit in the tabular list?
Factors influencing health status and contact with health services (Z00-Z99), in the block Resistance to antimicrobial drugs (Z16).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.