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Z22.7

Z22.7Latent tuberculosis

Billable / specific codeICD-10-CMPOA exempt

Z22.7 is a billable, specific ICD-10-CM code for latent tuberculosis. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis (R76.12)
  • nonspecific reaction to tuberculin skin test without active tuberculosis (R76.11)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Latent tuberculosis infection (LTBI)

Risk adjustment

Z22.7 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

Z22.7 is named in 3 Medicare coverage policies 3 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A58801Billing and Coding: Pharmacogenomics Testing
  • A58812Billing and Coding: Pharmacogenomics Testing
  • A59915Billing and Coding: Pharmacogenomic Testing

How Z22.7 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to Z22.7.

  • LTBI(latent tuberculosis infection)
  • Tuberculosis, tubercular, tuberculouslatent
  • Infection, infected, infectivetuberculouslatent(LTBI)
  • Tuberculosis, tubercular, tuberculousabscesslatent

Related codes at this level

Codes that share Z22. If Z22.7 is not quite right, the correct code is usually one of these.

Questions about Z22.7

Is Z22.7 a billable ICD-10-CM code?
Yes. Z22.7 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does Z22.7 sit in the tabular list?
Factors influencing health status and contact with health services (Z00-Z99), in the block Persons with potential health hazards related to communicable diseases (Z20-Z29).
What cannot be coded together with Z22.7?
Z22.7 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.