MCMCB Pro
ICD-10-CM tabular list

C81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue

ICD-10-CM codes C81-C96 cover malignant neoplasms of lymphoid, hematopoietic and related tissue, within neoplasms. The block holds 633 codes across 14 categories, of which 533 are billable and 100 are header codes that cannot be submitted on a claim.

Excludes2 — not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • Kaposi's sarcoma of lymph nodes (C46.3)
  • secondary and unspecified neoplasm of lymph nodes (C77.-)
  • secondary neoplasm of bone marrow (C79.52)
  • secondary neoplasm of spleen (C78.89)

Risk adjustment in C81-C96

0 codes in this block map to a CMS-HCC, which means the diagnosis carries a risk-adjustment payment when it is documented and coded. Under-coding here is money left on the table; over-coding here is what audits are for.

  • HCC 21 Lymphoma and Other Cancers
  • HCC 20 Lung and Other Severe Cancers
  • HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers
  • HCC 17 Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic
  • HCC 22 Bladder, Colorectal, and Other Cancers
  • HCC 18 Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid

What else to watch in C81-C96

  • 546 codes are named in Medicare coverage policies. An LCD or NCD lists them as supporting medical necessity, or explicitly as not supporting it. Which applies depends on the MAC for your state.

Categories in C81-C96

ICD-10-CMFY2026-Apr· effective April 1, 2026