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ICD-10-CM tabular list

Chapter 2: Neoplasms

C00-D49

Chapter 2 of the ICD-10-CM tabular list covers neoplasms, codes C00-D49. It holds 2,178 codes across 6 blocks, of which 1,727 are billable and 451 are header codes that cannot go on a claim.

Notes

Additional guidance from the ICD-10-CM tabular list.

  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Risk adjustment in Chapter 2

1,210 of this chapter’s codes map to a CMS-HCC, which means the diagnosis carries a risk-adjustment payment when it is documented and coded to the level the record supports.

  • HCC 21 Lymphoma and Other Cancers
  • HCC 20 Lung and Other Severe Cancers
  • HCC 23 Prostate, Breast, and Other Cancers and Tumors
  • HCC 22 Bladder, Colorectal, and Other Cancers
  • HCC 17 Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic
  • HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers

Blocks in this chapter

ICD-10-CMFY2026-Apr· effective April 1, 2026