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ICD-10-CM tabular list

E70-E88Metabolic disorders

ICD-10-CM codes E70-E88 cover metabolic disorders, within endocrine, nutritional and metabolic diseases. The block holds 366 codes across 17 categories, of which 286 are billable and 80 are header codes that cannot be submitted on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)

Excludes2 — not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • Ehlers-Danlos syndromes (Q79.6-)

Risk adjustment in E70-E88

0 codes in this block map to a CMS-HCC, which means the diagnosis carries a risk-adjustment payment when it is documented and coded. Under-coding here is money left on the table; over-coding here is what audits are for.

  • HCC 50 Amyloidosis, Porphyria, and Other Specified Metabolic Disorders
  • HCC 49 Specified Lysosomal Storage Disorders
  • HCC 277 Cystic Fibrosis

What else to watch in E70-E88

  • 202 codes are named in Medicare coverage policies. An LCD or NCD lists them as supporting medical necessity, or explicitly as not supporting it. Which applies depends on the MAC for your state.

Categories in E70-E88

ICD-10-CMFY2026-Apr· effective April 1, 2026