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D49.1

D49.1Neoplasm of unspecified behavior of respiratory system

Billable / specific codeICD-10-CM

D49.1 is a billable, specific ICD-10-CM code for neoplasm of unspecified behavior of respiratory system. It is valid for submission on a claim.

Other codes that can never be billed with D49.1

These codes carry an Excludes1 note pointing at D49.1. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D49.1 alone.

  • D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin

Risk adjustment

D49.1 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D49.1 is named in 18 Medicare coverage policies 18 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52450Billing and Coding: Paclitaxel (e.g., Taxol®/Abraxane ™)
  • A52480Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
  • A52986Billing and Coding: Biomarkers for Oncology
  • A53101Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID® Update

Related codes at this level

Codes that share D49. If D49.1 is not quite right, the correct code is usually one of these.

Questions about D49.1

Is D49.1 a billable ICD-10-CM code?
Yes. D49.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D49.1 sit in the tabular list?
Neoplasms (C00-D49), in the block Neoplasms of unspecified behavior (D49).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.