MCMCB Pro
Z15

Z15Genetic susceptibility to disease

Non-billable headerICD-10-CM

Z15 is a non-billable header ICD-10-CM code for genetic susceptibility to disease. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • chromosomal anomalies (Q90-Q99)

Use additional code

Add a secondary code to capture the detail described below.

  • code, if applicable, for any associated family history of the disease (Z80-Z84)

Includes

Conditions this code covers.

  • confirmed abnormal gene

Risk adjustment

Z15 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code to one of these instead Z15

5 child codes. Green means billable.

Questions about Z15

Is Z15 a billable ICD-10-CM code?
No. Z15 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does Z15 sit in the tabular list?
Factors influencing health status and contact with health services (Z00-Z99), in the block Genetic carrier and genetic susceptibility to disease (Z14-Z15).
What cannot be coded together with Z15?
Z15 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.