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Z15.81

Z15.81Genetic susceptibility to multiple endocrine neoplasia [MEN]

Billable / specific codeICD-10-CMPOA exempt

Z15.81 is a billable, specific ICD-10-CM code for genetic susceptibility to multiple endocrine neoplasia [men]. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • multiple endocrine neoplasia [MEN] syndromes (E31.2-)

Risk adjustment

Z15.81 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

How Z15.81 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to Z15.81.

  • Susceptibility to disease, geneticmultiple endocrine neoplasia
  • Geneticsusceptibility to disease NECmultiple endocrine neoplasia

Related codes at this level

Codes that share Z15.8. If Z15.81 is not quite right, the correct code is usually one of these.

Questions about Z15.81

Is Z15.81 a billable ICD-10-CM code?
Yes. Z15.81 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does Z15.81 sit in the tabular list?
Factors influencing health status and contact with health services (Z00-Z99), in the block Genetic carrier and genetic susceptibility to disease (Z14-Z15).
What cannot be coded together with Z15.81?
Z15.81 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.