C2621 — Pacemaker, other than single or dual chamber (implantable)
C2621 is a HCPCS Level II code for pacemaker, other than single or dual chamber (implantable). It belongs to the Outpatient Prospective Payment System section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Medically Unlikely Edits — units per day
The most units of C2621 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 1 unit MAI 3 — Date of Service Edit: Clinical · Nature of Equipment
- outpatient
- 1 unit MAI 3 — Date of Service Edit: Clinical · Nature of Equipment
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for C2621
- Long descriptor
- Pacemaker, other than single or dual chamber (implantable)
- Short descriptor
- Pmkr, other than sing/dual
- Added
- April 1, 2001
- BETOS
- D1A
- Pricing indicator
- 53 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Statute.
Codes adjacent to C2621
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If C2621 is not quite right, the correct code is very often within a few positions of it.
- C2613Lung biopsy plug with delivery system
- C2614Probe, percutaneous lumbar discectomy
- C2615Sealant, pulmonary, liquid
- C2616Brachytherapy source, non-stranded, yttrium-90, per source
- C2617Stent, non-coronary, temporary, without delivery system
- C2618Probe/needle, cryoablation
- C2619Pacemaker, dual chamber, non rate-responsive (implantable)
- C2620Pacemaker, single chamber, non rate-responsive (implantable)
- C2622Prosthesis, penile, non-inflatable
- C2623Catheter, transluminal angioplasty, drug-coated, non-laser
- C2624Implantable wireless pulmonary artery pressure sensor with delivery catheter, including all system components
- C2625Stent, non-coronary, temporary, with delivery system
- C2626Infusion pump, non-programmable, temporary (implantable)
- C2627Catheter, suprapubic/cystoscopic
- C2628Catheter, occlusion
- C2629Introducer/sheath, other than guiding, other than intracardiac electrophysiological, laser
Questions about C2621
What is HCPCS code C2621?
C2621 is a HCPCS Level II code for pacemaker, other than single or dual chamber (implantable). It sits in the Outpatient Prospective Payment System section.
Does Medicare cover C2621?
The CMS HCPCS file marks C2621 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.