MCMCB Pro
G2182

G2182Patient receiving first-time biologic and/or immune response modifier therapy

HCPCSActiveBETOS Z2

G2182 is a HCPCS Level II code for patient receiving first-time biologic and/or immune response modifier therapy. It belongs to the Procedures and Professional Services (Temporary) section. Whether Medicare pays it depends on the coverage rule below.

Medicare coverage: Carrier judgment

Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.

From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.

Physician fee schedule statusM

Measurement code. Used for reporting purposes only; never paid.

Global period: XXX

Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.

The CMS record for G2182

Long descriptor
Patient receiving first-time biologic and/or immune response modifier therapy

The official wording. This is what the code means.

Short descriptor
Pt 1st biolog antirheum

CMS's 28-character form, which is what shows up on a remittance advice.

Added
January 1, 2021

When CMS introduced the code.

BETOS
Z2

Berenson-Eggers Type of Service — CMS's own analytic grouping.

Pricing indicator
00 — Not priced by Part B

Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.

Codes adjacent to G2182

HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If G2182 is not quite right, the correct code is very often within a few positions of it.

  • G2174Uri episodes where the patient is taking antibiotics (table 1) in the 30 days prior to the episode date
  • G2175Episodes where the patient had a comorbid condition during the 12 months prior to or on the episode date (e.g., tuberculosis, neutropenia, cystic fibrosis, chronic bronchitis, pulmonary edema, respiratory failure, rheumatoid lung disease)
  • G2176Outpatient, ed, or observation visits that result in an inpatient admission
  • G2177Acute bronchitis/bronchiolitis episodes when the patient had a new or refill prescription of antibiotics (table 1) in the 30 days prior to the episode date
  • G2178Clinician documented that patient was not an eligible candidate for lower extremity neurological exam measure, for example patient bilateral amputee; patient has condition that would not allow them to accurately respond to a neurological exam (dementia, alzheimer's, etc.); patient has previously documented diabetic peripheral neuropathy with loss of protective sensation
  • G2179Clinician documented that patient had medical reason for not performing lower extremity neurological exam
  • G2180Clinician documented that patient was not an eligible candidate for evaluation of footwear as patient is bilateral lower extremity amputee
  • G2181Bmi not documented due to medical reason or patient refusal of height or weight measurement
  • G2183Documentation patient unable to communicate and informant not available
  • G2184Patient does not have a caregiver
  • G2185Documentation caregiver is trained and certified in dementia care
  • G2186Patient /caregiver dyad has been referred to appropriate resources and connection to those resources is confirmed
  • G2187Patients with clinical indications for imaging of the head: head trauma
  • G2188Patients with clinical indications for imaging of the head: new or change in headache above 50 years of age
  • G2189Patients with clinical indications for imaging of the head: abnormal neurologic exam
  • G2190Patients with clinical indications for imaging of the head: headache radiating to the neck

Questions about G2182

What is HCPCS code G2182?

G2182 is a HCPCS Level II code for patient receiving first-time biologic and/or immune response modifier therapy. It sits in the Procedures and Professional Services (Temporary) section.

Does Medicare cover G2182?

The CMS HCPCS file marks G2182 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.

How is G2182 paid under the physician fee schedule?

G2182 carries PFS status code M. Measurement code. Used for reporting purposes only; never paid.

HCPCS Level II2026Q3-Jul· effective July 1, 2026