J0458 — Injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg)
J0458 is a HCPCS Level II code for injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg). It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
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The CMS record for J0458
- Long descriptor
- Injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg)
- Short descriptor
- Aztreonam/avibactam 10 mg
- Added
- October 1, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J0458
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J0458 is not quite right, the correct code is very often within a few positions of it.
- J0390Injection, chloroquine hydrochloride, up to 250 mg
- J0391Injection, artesunate, 1 mg
- J0395Injection, arbutamine hcl, 1 mgterminated
- J0400Injection, aripiprazole, intramuscular, 0.25 mg
- J0401Injection, aripiprazole (abilify maintena), 1 mg
- J0402Injection, aripiprazole (abilify asimtufii), 1 mg
- J0456Injection, azithromycin, 500 mg
- J0457Injection, aztreonam, 100 mg
- J0461Injection, atropine sulfate, 0.01 mg
- J0462Injection, atropine sulfate, not therapeutically equivalent to j0461, 0.01 mg
- J0463Injection, atropine sulfate (fresenius and therapeutically equivalent), 0.01 mg
- J0470Injection, dimercaprol, per 100 mg
- J0475Injection, baclofen, 10 mg
- J0476Injection, baclofen, 50 mcg for intrathecal trial
- J0480Injection, basiliximab, 20 mg
- J0485Injection, belatacept, 1 mg
Questions about J0458
What is HCPCS code J0458?
J0458 is a HCPCS Level II code for injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg). It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J0458?
The CMS HCPCS file marks J0458 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
How is J0458 paid under the physician fee schedule?
J0458 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).