J0666 — Injection, bupivacaine liposome, 1 mg
J0666 is a HCPCS Level II code for injection, bupivacaine liposome, 1 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
Medically Unlikely Edits — units per day
The most units of J0666 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 266 units MAI 2 — Date of Service Edit: Policy · Anatomic Consideration
- outpatient
- 266 units MAI 2 — Date of Service Edit: Policy · Anatomic Consideration
- DME supplier
- 266 units MAI 2 — Date of Service Edit: Policy · Anatomic Consideration
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for J0666
- Long descriptor
- Injection, bupivacaine liposome, 1 mg
- Short descriptor
- Inj, bupivacaine liposome
- Added
- January 1, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J0666
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J0666 is not quite right, the correct code is very often within a few positions of it.
- J0640Injection, leucovorin calcium, per 50 mg
- J0641Injection, levoleucovorin, not otherwise specified, 0.5 mg
- J0642Injection, levoleucovorin (khapzory), 0.5 mg
- J0650Injection, levothyroxine sodium, not otherwise specified, 10 mcg
- J0651Injection, levothyroxine sodium (fresenius kabi), not therapeutically equivalent to j0650, 10 mcg
- J0652Injection, levothyroxine sodium (hikma), not therapeutically equivalent to j0650, 10 mcg
- J0654Injection, liothyronine, 1 mcg
- J0665Injection, bupivicaine, not otherwise specified, 0.5 mg
- J0668Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
- J0670Injection, mepivacaine hydrochloride, per 10 ml
- J0675Injection, carboprost tromethamine, 0.1 mg
- J0681Injection, ceftobiprole medocaril sodium, 3 mg
- J0687Injection, cefazolin sodium (wg critical care), not therapeutically equivalent to j0690, 500 mg
- J0688Injection, cefazolin sodium (hikma), not therapeutically equivalent to j0690, 500 mg
- J0689Injection, cefazolin sodium (baxter), not therapeutically equivalent to j0690, 500 mg
- J0690Injection, cefazolin sodium, 500 mg
Questions about J0666
What is HCPCS code J0666?
J0666 is a HCPCS Level II code for injection, bupivacaine liposome, 1 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J0666?
The CMS HCPCS file marks J0666 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
How is J0666 paid under the physician fee schedule?
J0666 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).