J1558 — Injection, immune globulin (xembify), 100 mg
J1558 is a HCPCS Level II code for injection, immune globulin (xembify), 100 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
Medically Unlikely Edits — units per day
The most units of J1558 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 480 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- outpatient
- 480 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- DME supplier
- 1500 units MAI 3 — Date of Service Edit: Clinical · Clinical: CMS Workgroup
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for J1558
- Long descriptor
- Injection, immune globulin (xembify), 100 mg
- Short descriptor
- Inj. xembify, 100 mg
- Added
- July 1, 2020
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J1558
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J1558 is not quite right, the correct code is very often within a few positions of it.
- J1460Injection, gamma globulin, intramuscular, 1 cc
- J1551Injection, immune globulin (cutaquig), 100 mg
- J1552Injection, immune globulin (alyglo), 500 mg
- J1553Injection, immune globulin (yimmugo), 100 mg
- J1554Injection, immune globulin (asceniv), 500 mg
- J1555Injection, immune globulin (cuvitru), 100 mg
- J1556Injection, immune globulin (bivigam), 500 mg
- J1557Injection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g., liquid), 500 mg
- J1559Injection, immune globulin (hizentra), 100 mg
- J1560Injection, gamma globulin, intramuscular, over 10 cc
- J1561Injection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mg
- J1562Injection, immune globulin (vivaglobin), 100 mgterminated
- J1566Injection, immune globulin, intravenous, lyophilized (e.g., powder), not otherwise specified, 500 mg
- J1568Injection, immune globulin, (octagam), intravenous, non-lyophilized (e.g., liquid), 500 mg
- J1569Injection, immune globulin, (gammagard liquid/gammagard liquid erc), 500 mg
- J1570Injection, ganciclovir sodium, 500 mg
Questions about J1558
What is HCPCS code J1558?
J1558 is a HCPCS Level II code for injection, immune globulin (xembify), 100 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J1558?
The CMS HCPCS file marks J1558 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
How is J1558 paid under the physician fee schedule?
J1558 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).