J2151 — Injection, mannitol, 250 mg
J2151 is a HCPCS Level II code for injection, mannitol, 250 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for J2151
- Long descriptor
- Injection, mannitol, 250 mg
- Short descriptor
- Inj, mannitol, 250 mg
- Added
- October 1, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J2151
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J2151 is not quite right, the correct code is very often within a few positions of it.
- J2003Injection, lidocaine hydrochloride, 1 mg
- J2004Injection, lidocaine hcl with epinephrine, 1 mg
- J2010Injection, lincomycin hcl, up to 300 mg
- J2020Injection, linezolid, 200 mg
- J2021Injection, linezolid (hospira), not therapeutically equivalent to j2020, 200 mg
- J2060Injection, lorazepam, 2 mg
- J2062Loxapine for inhalation, 1 mg
- J2150Injection, mannitol, 25% in 50 mlterminated
- J2170Injection, mecasermin, 1 mg
- J2175Injection, meperidine hydrochloride, per 100 mg
- J2180Injection, meperidine and promethazine hcl, up to 50 mg
- J2182Injection, mepolizumab, 1 mg
- J2183Injection, meropenem (wg critical care), not therapeutically equivalent to j2185, 100 mg
- J2184Injection, meropenem (b. braun), not therapeutically equivalent to j2185, 100 mg
- J2185Injection, meropenem, 100 mg
- J2186Injection, meropenem and vaborbactam, 10mg/10mg (20mg)
Questions about J2151
What is HCPCS code J2151?
J2151 is a HCPCS Level II code for injection, mannitol, 250 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J2151?
The CMS HCPCS file marks J2151 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
How is J2151 paid under the physician fee schedule?
J2151 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).