J2995 — Injection, streptokinase, per 250,000 iu
J2995 is a HCPCS Level II code for injection, streptokinase, per 250,000 iu. It belongs to the Drugs Administered Other Than Oral Method section. It was terminated on December 31, 2025 and is not valid on new claims.
This code has been terminated
CMS terminated J2995 on December 31, 2025. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for J2995
- Long descriptor
- Injection, streptokinase, per 250,000 iu
- Short descriptor
- Inj streptokinase /250000 iu
- Added
- January 1, 1986
- Terminated
- December 31, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J2995
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J2995 is not quite right, the correct code is very often within a few positions of it.
- J2916Injection, sodium ferric gluconate complex in sucrose injection, 12.5 mg
- J2919Injection, methylprednisolone sodium succinate, 5 mg
- J2920Injection, methylprednisolone sodium succinate, up to 40 mgterminated
- J2930Injection, methylprednisolone sodium succinate, up to 125 mgterminated
- J2940Injection, somatrem, 1 mgterminated
- J2941Injection, somatropin, 1 mg
- J2950Injection, promazine hcl, up to 25 mg
- J2993Injection, reteplase, 18.1 mg
- J2997Injection, alteplase recombinant, 1 mg
- J2998Injection, plasminogen, human-tvmh, 1 mg
- J3000Injection, streptomycin, up to 1 gm
- J3010Injection, fentanyl citrate, 0.1 mg
- J3030Injection, sumatriptan succinate, 6 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
- J3031Injection, fremanezumab-vfrm, 1 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self-administered)
- J3032Injection, eptinezumab-jjmr, 1 mg
- J3055Injection, talquetamab-tgvs, 0.25 mg
Questions about J2995
What is HCPCS code J2995?
J2995 is a HCPCS Level II code for injection, streptokinase, per 250,000 iu. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J2995?
The CMS HCPCS file marks J2995 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
Is J2995 still valid?
No. J2995 was terminated on December 31, 2025 and should not be used on new claims.