Q4221 — Amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure)
Q4221 is a HCPCS Level II code for amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure). It belongs to the Temporary Codes section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusA
Active code. Paid separately under the physician fee schedule.
- Work RVU
- 0.00
- PE (non-facility)
- 3.81
- PE (facility)
- 3.81
- Malpractice RVU
- 0.00
Global period: ZZZ
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The CMS record for Q4221
- Long descriptor
- Amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure)
- Short descriptor
- Amniowrap2 per sq cm
- Added
- October 1, 2019
- BETOS
- O1E
- Pricing indicator
- 11 — Physician fee schedule
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Price established using national RVUs.
Codes adjacent to Q4221
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If Q4221 is not quite right, the correct code is very often within a few positions of it.
- Q4213Ascent, 0.5 mg
- Q4214Cellesta cord, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4215Axolotl ambient or axolotl cryo, 0.1 mg
- Q4216Artacent cord, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4217Woundfix, biowound, woundfix plus, biowound plus, woundfix xplus or biowound xplus, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4218Surgicord, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4219Surgigraft-dual, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4220Bellacell hd or surederm, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4222Progenamatrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4224Human health factor 10 amniotic patch (hhf10-p), per square centimeter (add-on, list separately in addition to primary procedure)
- Q4225Amniobind or dermabind tl, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4226Myown skin, includes harvesting and preparation procedures, per square centimeter
- Q4227Amniocore, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4228Bionextpatch, per square centimeterterminated
- Q4229Cogenex amniotic membrane, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4230Cogenex flowable amnion, per 0.5 cc
Questions about Q4221
What is HCPCS code Q4221?
Q4221 is a HCPCS Level II code for amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure). It sits in the Temporary Codes section.
Does Medicare cover Q4221?
The CMS HCPCS file marks Q4221 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
How is Q4221 paid under the physician fee schedule?
Q4221 carries PFS status code A. Active code. Paid separately under the physician fee schedule.