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Q5104

Q5104Injection, infliximab-abda, biosimilar, (renflexis), 10 mg

HCPCSActiveBETOS O1E

Q5104 is a HCPCS Level II code for injection, infliximab-abda, biosimilar, (renflexis), 10 mg. It belongs to the Temporary Codes section. Whether Medicare pays it depends on the coverage rule below.

Medicare coverage: Special coverage instructions apply

There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.

From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.

Physician fee schedule statusE

Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).

Global period: XXX

Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.

Medically Unlikely Edits — units per day

The most units of Q5104 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.

practitioner
150 units
MAI 3 — Date of Service Edit: Clinical · Prescribing Information
outpatient
150 units
MAI 3 — Date of Service Edit: Clinical · Prescribing Information
DME supplier
0 — never payable
MAI 3 — Date of Service Edit: Clinical · CMS Policy

The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.

The CMS record for Q5104

Long descriptor
Injection, infliximab-abda, biosimilar, (renflexis), 10 mg

The official wording. This is what the code means.

Short descriptor
Injection, renflexis

CMS's 28-character form, which is what shows up on a remittance advice.

Added
April 1, 2018

When CMS introduced the code.

BETOS
O1E

Berenson-Eggers Type of Service — CMS's own analytic grouping.

Pricing indicator
51 — Other

Drugs.

Codes adjacent to Q5104

HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If Q5104 is not quite right, the correct code is very often within a few positions of it.

  • Q5009Hospice or home health care provided in place not otherwise specified (nos)
  • Q5010Hospice home care provided in a hospice facility
  • Q5098Injection, ustekinumab-srlf (imuldosa), biosimilar, 1 mg
  • Q5099Injection, ustekinumab-stba (steqeyma), biosimilar, 1 mg
  • Q5100Injection, ustekinumab-kfce (yesintek), biosimilar, 1 mg
  • Q5101Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram
  • Q5102Injection, infliximab, biosimilar, 10 mgterminated
  • Q5103Injection, infliximab-dyyb, biosimilar, (inflectra), 10 mg
  • Q5105Injection, epoetin alfa-epbx, biosimilar, (retacrit) (for esrd on dialysis), 100 units
  • Q5106Injection, epoetin alfa-epbx, biosimilar, (retacrit) (for non-esrd use), 1000 units
  • Q5107Injection, bevacizumab-awwb, biosimilar, (mvasi), 10 mg
  • Q5108Injection, pegfilgrastim-jmdb (fulphila), biosimilar, 0.5 mg
  • Q5109Injection, infliximab-qbtx, biosimilar, (ixifi), 10 mgterminated
  • Q5110Injection, filgrastim-aafi, biosimilar, (nivestym), 1 microgram
  • Q5111Injection, pegfilgrastim-cbqv (udenyca), biosimilar, 0.5 mg
  • Q5112Injection, trastuzumab-dttb, biosimilar, (ontruzant), 10 mg

Questions about Q5104

What is HCPCS code Q5104?

Q5104 is a HCPCS Level II code for injection, infliximab-abda, biosimilar, (renflexis), 10 mg. It sits in the Temporary Codes section.

Does Medicare cover Q5104?

The CMS HCPCS file marks Q5104 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.

How is Q5104 paid under the physician fee schedule?

Q5104 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).

HCPCS Level II2026Q3-Jul· effective July 1, 2026