S3855 — Genetic testing for detection of mutations in the presenilin - 1 gene
S3855 is a HCPCS Level II code for genetic testing for detection of mutations in the presenilin - 1 gene. It belongs to the Temporary National Codes (Non-Medicare) section. It was terminated on December 31, 2014 and is not valid on new claims.
This code has been terminated
CMS terminated S3855 on December 31, 2014. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for S3855
- Long descriptor
- Genetic testing for detection of mutations in the presenilin - 1 gene
- Short descriptor
- Gene test presenilin-1 gene
- Added
- January 1, 2007
- Terminated
- December 31, 2014
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S3855
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S3855 is not quite right, the correct code is very often within a few positions of it.
- S3844Dna analysis of the connexin 26 gene (gjb2) for susceptibility to congenital, profound deafness
- S3845Genetic testing for alpha-thalassemia
- S3846Genetic testing for hemoglobin e beta-thalassemia
- S3849Genetic testing for niemann-pick disease
- S3850Genetic testing for sickle cell anemia
- S3852Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease
- S3853Genetic testing for myotonic muscular dystrophy
- S3854Gene expression profiling panel for use in the management of breast cancer treatment
- S3861Genetic testing, sodium channel, voltage-gated, type v, alpha subunit (scn5a) and variants for suspected brugada syndrome
- S3865Comprehensive gene sequence analysis for hypertrophic cardiomyopathy
- S3866Genetic analysis for a specific gene mutation for hypertrophic cardiomyopathy (hcm) in an individual with a known hcm mutation in the family
- S3870Comparative genomic hybridization (cgh) microarray testing for developmental delay, autism spectrum disorder and/or intellectual disability
- S3890Dna analysis, fecal, for colorectal cancer screeningterminated
- S3900Surface electromyography (emg)
- S3902Ballistocardiogram
- S3904Masters two step
Questions about S3855
What is HCPCS code S3855?
S3855 is a HCPCS Level II code for genetic testing for detection of mutations in the presenilin - 1 gene. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S3855?
The CMS HCPCS file marks S3855 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
Is S3855 still valid?
No. S3855 was terminated on December 31, 2014 and should not be used on new claims.