E16.4 — Increased secretion of gastrin
E16.4 is a billable, specific ICD-10-CM code for increased secretion of gastrin. It is valid for submission on a claim.
Inclusion terms
Alternative wordings a physician may use in the chart for this same code.
- Hypergastrinemia
- Hyperplasia of pancreatic endocrine cells with gastrin excess
- Zollinger-Ellison syndrome
Other codes that can never be billed with E16.4
These codes carry an Excludes1 note pointing at E16.4. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading E16.4 alone.
- K29Gastritis and duodenitis
Risk adjustment
E16.4 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.
Medicare coverage
E16.4 is named in 7 Medicare coverage policies — 7 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.
- A56421Billing and Coding: CT of the Abdomen and Pelvis
- A57063Billing and Coding: Diagnostic and Therapeutic Esophagogastroduodenoscopy
- A57361Billing and Coding: Monitored Anesthesia Care
- A57753Billing and Coding: Wireless Capsule Endoscopy
How E16.4 is indexed
Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E16.4.
- Ellison-Zollinger syndrome
- Hypergastrinemia
- Zollinger-Ellison syndrome
- Abnormal, abnormality, abnormalities›gastrin secretion
- Hypersecretion›gastrin
- Abnormal, abnormality, abnormalities›secretion›gastrin
- Increase, increased›secretion›gastrin
- Hyperplasia, hyperplastic›pancreatic islet cells›alpha›with excess›gastrin
Related codes at this level
Codes that share E16. If E16.4 is not quite right, the correct code is usually one of these.
Questions about E16.4
- Is E16.4 a billable ICD-10-CM code?
- Yes. E16.4 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
- Where does E16.4 sit in the tabular list?
- Endocrine, nutritional and metabolic diseases (E00-E89), in the block Other disorders of glucose regulation and pancreatic internal secretion (E15-E16).