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E16.8

E16.8Other specified disorders of pancreatic internal secretion

Billable / specific codeICD-10-CM

E16.8 is a billable, specific ICD-10-CM code for other specified disorders of pancreatic internal secretion. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Increased secretion from endocrine pancreas of growth hormone-releasing hormone
  • Increased secretion from endocrine pancreas of pancreatic polypeptide
  • Increased secretion from endocrine pancreas of somatostatin
  • Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide

Other codes that can never be billed with E16.8

These codes carry an Excludes1 note pointing at E16.8. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading E16.8 alone.

  • E22.0Acromegaly and pituitary gigantism

Risk adjustment

E16.8 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E16.8 is named in 4 Medicare coverage policies 4 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article
  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A57361Billing and Coding: Monitored Anesthesia Care

How E16.8 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E16.8.

  • Disorderpancreatic internal secretionspecified NEC
  • Hyperplasia, hyperplasticpancreatic islet cellsalpha
  • Increase, increasedsecretionpancreas, endocrinegrowth hormone-releasing hormone
  • Increase, increasedsecretionpancreas, endocrinepancreatic polypeptide
  • Increase, increasedsecretionpancreas, endocrinesomatostatin
  • Increase, increasedsecretionpancreas, endocrinevasoactive-intestinal polypeptide

Related codes at this level

Codes that share E16. If E16.8 is not quite right, the correct code is usually one of these.

Questions about E16.8

Is E16.8 a billable ICD-10-CM code?
Yes. E16.8 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E16.8 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Other disorders of glucose regulation and pancreatic internal secretion (E15-E16).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.