J0281 — Injection, aminocaproic acid, 1 gram
J0281 is a HCPCS Level II code for injection, aminocaproic acid, 1 gram. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
Medically Unlikely Edits — units per day
The most units of J0281 Medicare will pay on one date of service. Bill more on a single line and it is denied. The limit is not the same in every setting, so the row that matters is the one matching the claim you are building.
- practitioner
- 30 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- outpatient
- 30 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
- DME supplier
- 30 units MAI 3 — Date of Service Edit: Clinical · Prescribing Information
The adjudication indicator decides whether exceeding the limit is worth appealing at all: MAI 1 is a line edit you can support with documentation, MAI 3 is a date-of-service edit that is also appealable, and MAI 2 is absolute — no documentation overrides it. CMS MUE 2026Q3.
The CMS record for J0281
- Long descriptor
- Injection, aminocaproic acid, 1 gram
- Short descriptor
- Inj aminocaproic acid 1 gram
- Added
- April 1, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J0281
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J0281 is not quite right, the correct code is very often within a few positions of it.
- J0225Injection, vutrisiran, 1 mg
- J0248Injection, remdesivir, 1 mg
- J0256Injection, alpha 1 proteinase inhibitor (human), not otherwise specified, 10 mg
- J0257Injection, alpha 1 proteinase inhibitor (human), (glassia), 10 mg
- J0270Injection, alprostadil, 1.25 mcg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
- J0275Alprostadil urethral suppository (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
- J0278Injection, amikacin sulfate, 100 mg
- J0280Injection, aminophyllin, up to 250 mg
- J0282Injection, amiodarone hydrochloride, 30 mg
- J0283Injection, amiodarone hydrochloride (nexterone), 30 mg
- J0285Injection, amphotericin b, 50 mg
- J0287Injection, amphotericin b lipid complex, 10 mg
- J0288Injection, amphotericin b cholesteryl sulfate complex, 10 mgterminated
- J0289Injection, amphotericin b liposome, 10 mg
- J0290Injection, ampicillin sodium, 500 mg
- J0291Injection, plazomicin, 5 mg
Questions about J0281
What is HCPCS code J0281?
J0281 is a HCPCS Level II code for injection, aminocaproic acid, 1 gram. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J0281?
The CMS HCPCS file marks J0281 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
How is J0281 paid under the physician fee schedule?
J0281 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).