J2291 — Injection, nafcillin sodium (baxter), 20 mg
J2291 is a HCPCS Level II code for injection, nafcillin sodium (baxter), 20 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusE
Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).
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The CMS record for J2291
- Long descriptor
- Injection, nafcillin sodium (baxter), 20 mg
- Short descriptor
- Inj, nafcillin (baxter) 20mg
- Added
- October 1, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J2291
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J2291 is not quite right, the correct code is very often within a few positions of it.
- J2272Injection, morphine sulfate (fresenius kabi), not therapeutically equivalent to j2270, up to 10 mg
- J2274Injection, morphine sulfate, preservative-free for epidural or intrathecal use, 10 mg
- J2275Injection, morphine sulfate (preservative-free sterile solution), per 10 mgterminated
- J2277Injection, motixafortide, 0.25 mg
- J2278Injection, ziconotide, 1 microgram
- J2280Injection, moxifloxacin, 100 mg
- J2281Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg
- J2290Injection, nafcillin sodium, 20 mg
- J2300Injection, nalbuphine hydrochloride, per 10 mg
- J2305Injection, nitroglycerin, 5 mg
- J2310Injection, naloxone hydrochloride, per 1 mgterminated
- J2311Injection, naloxone hydrochloride (zimhi), 1 mgterminated
- J2312Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
- J2313Injection, naloxone hydrochloride (zimhi), 0.01 mg
- J2315Injection, naltrexone, depot form, 1 mg
- J2320Injection, nandrolone decanoate, up to 50 mg
Questions about J2291
What is HCPCS code J2291?
J2291 is a HCPCS Level II code for injection, nafcillin sodium (baxter), 20 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J2291?
The CMS HCPCS file marks J2291 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
How is J2291 paid under the physician fee schedule?
J2291 carries PFS status code E. Excluded from the physician fee schedule by regulation. Payment, where it exists, comes from another fee schedule (drugs via ASP, supplies via DMEPOS, and so on).