J2310 — Injection, naloxone hydrochloride, per 1 mg
J2310 is a HCPCS Level II code for injection, naloxone hydrochloride, per 1 mg. It belongs to the Drugs Administered Other Than Oral Method section. It was terminated on June 30, 2025 and is not valid on new claims.
This code has been terminated
CMS terminated J2310 on June 30, 2025. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for J2310
- Long descriptor
- Injection, naloxone hydrochloride, per 1 mg
- Short descriptor
- Inj naloxone hydrochloride
- Added
- January 1, 1996
- Terminated
- June 30, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to J2310
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If J2310 is not quite right, the correct code is very often within a few positions of it.
- J2277Injection, motixafortide, 0.25 mg
- J2278Injection, ziconotide, 1 microgram
- J2280Injection, moxifloxacin, 100 mg
- J2281Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mg
- J2290Injection, nafcillin sodium, 20 mg
- J2291Injection, nafcillin sodium (baxter), 20 mg
- J2300Injection, nalbuphine hydrochloride, per 10 mg
- J2305Injection, nitroglycerin, 5 mg
- J2311Injection, naloxone hydrochloride (zimhi), 1 mgterminated
- J2312Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
- J2313Injection, naloxone hydrochloride (zimhi), 0.01 mg
- J2315Injection, naltrexone, depot form, 1 mg
- J2320Injection, nandrolone decanoate, up to 50 mg
- J2323Injection, natalizumab, 1 mg
- J2325Injection, nesiritide, 0.1 mg
- J2326Injection, nusinersen, 0.1 mg
Questions about J2310
What is HCPCS code J2310?
J2310 is a HCPCS Level II code for injection, naloxone hydrochloride, per 1 mg. It sits in the Drugs Administered Other Than Oral Method section.
Does Medicare cover J2310?
The CMS HCPCS file marks J2310 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
Is J2310 still valid?
No. J2310 was terminated on June 30, 2025 and should not be used on new claims.