S0013 — Esketamine, nasal spray, 1 mg
S0013 is a HCPCS Level II code for esketamine, nasal spray, 1 mg. It belongs to the Temporary National Codes (Non-Medicare) section. It was terminated on December 31, 2025 and is not valid on new claims.
This code has been terminated
CMS terminated S0013 on December 31, 2025. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for S0013
- Long descriptor
- Esketamine, nasal spray, 1 mg
- Short descriptor
- Esketamine, nasal spray
- Added
- January 1, 2021
- Terminated
- December 31, 2025
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S0013
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S0013 is not quite right, the correct code is very often within a few positions of it.
- Q9996Injection, ustekinumab-ttwe (pyzchiva), subcutaneous, 1 mg
- Q9997Injection, ustekinumab-ttwe (pyzchiva), intravenous, 1 mg
- Q9998Injection, ustekinumab-aekn (selarsdi), biosimilar, 1 mg
- Q9999Injection, ustekinumab-aauz (otulfi), biosimilar, 1 mg
- R0070Transportation of portable x-ray equipment and personnel to home or nursing home, per trip to facility or location, one patient seen
- R0075Transportation of portable x-ray equipment and personnel to home or nursing home, per trip to facility or location, more than one patient seen
- R0076Transportation of portable ekg to facility or location, per patient
- S0012Butorphanol tartrate, nasal spray, 25 mg
- S0014Tacrine hydrochloride, 10 mg
- S0017Injection, aminocaproic acid, 5 gramsterminated
- S0020Injection, bupivicaine hydrochloride, 30 mlterminated
- S0021Injection, cefoperazone sodium, 1 gram
- S0023Injection, cimetidine hydrochloride, 300 mg
- S0028Injection, famotidine, 20 mgterminated
- S0030Injection, metronidazole, 500 mgterminated
- S0032Injection, nafcillin sodium, 2 gramsterminated
Questions about S0013
What is HCPCS code S0013?
S0013 is a HCPCS Level II code for esketamine, nasal spray, 1 mg. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S0013?
The CMS HCPCS file marks S0013 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
Is S0013 still valid?
No. S0013 was terminated on December 31, 2025 and should not be used on new claims.