S0081 — Injection, piperacillin sodium, 500 mg
S0081 is a HCPCS Level II code for injection, piperacillin sodium, 500 mg. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S0081
- Long descriptor
- Injection, piperacillin sodium, 500 mg
- Short descriptor
- Injection, piperacillin sodi
- Added
- January 1, 2000
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S0081
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S0081 is not quite right, the correct code is very often within a few positions of it.
- S0034Injection, ofloxacin, 400 mg
- S0039Injection, sulfamethoxazole and trimethoprim, 10 mlterminated
- S0040Injection, ticarcillin disodium and clavulanate potassium, 3.1 grams
- S0073Injection, aztreonam, 500 mgterminated
- S0074Injection, cefotetan disodium, 500 mgterminated
- S0077Injection, clindamycin phosphate, 300 mgterminated
- S0078Injection, fosphenytoin sodium, 750 mg
- S0080Injection, pentamidine isethionate, 300 mgterminated
- S0088Imatinib, 100 mg
- S0090Sildenafil citrate, 25 mg
- S0091Granisetron hydrochloride, 1 mg (for circumstances falling under the medicare statute, use q0166)
- S0092Injection, hydromorphone hydrochloride, 250 mg (loading dose for infusion pump)
- S0093Injection, morphine sulfate, 500 mg (loading dose for infusion pump)
- S0104Zidovudine, oral, 100 mg
- S0106Bupropion hcl sustained release tablet, 150 mg, per bottle of 60 tablets
- S0108Mercaptopurine, oral, 50 mg
Questions about S0081
What is HCPCS code S0081?
S0081 is a HCPCS Level II code for injection, piperacillin sodium, 500 mg. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S0081?
The CMS HCPCS file marks S0081 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S0081 paid under the physician fee schedule?
S0081 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.