S3721 — Prostate cancer antigen 3 (pca3) testing
S3721 is a HCPCS Level II code for prostate cancer antigen 3 (pca3) testing. It belongs to the Temporary National Codes (Non-Medicare) section. It was terminated on December 31, 2015 and is not valid on new claims.
This code has been terminated
CMS terminated S3721 on December 31, 2015. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for S3721
- Long descriptor
- Prostate cancer antigen 3 (pca3) testing
- Short descriptor
- Pca3 testing
- Added
- April 1, 2012
- Terminated
- December 31, 2015
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S3721
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S3721 is not quite right, the correct code is very often within a few positions of it.
- S3601Emergency stat laboratory charge for patient who is homebound or residing in a nursing facility
- S3620Newborn metabolic screening panel, includes test kit, postage and the laboratory tests specified by the state for inclusion in this panel (e.g., galactose; hemoglobin, electrophoresis; hydroxyprogesterone, 17-d; phenylalanine (pku); and thyroxine, total)
- S3630Eosinophil count, blood, direct
- S3645Hiv-1 antibody testing of oral mucosal transudate
- S3650Saliva test, hormone level; during menopause
- S3652Saliva test, hormone level; to assess preterm labor risk
- S3655Antisperm antibodies test (immunobead)
- S3708Gastrointestinal fat absorption study
- S3722Dose optimization by area under the curve (auc) analysis, for infusional 5-fluorouracil
- S3800Genetic testing for amyotrophic lateral sclerosis (als)
- S3840Dna analysis for germline mutations of the ret proto-oncogene for susceptibility to multiple endocrine neoplasia type 2
- S3841Genetic testing for retinoblastoma
- S3842Genetic testing for von hippel-lindau disease
- S3844Dna analysis of the connexin 26 gene (gjb2) for susceptibility to congenital, profound deafness
- S3845Genetic testing for alpha-thalassemia
- S3846Genetic testing for hemoglobin e beta-thalassemia
Questions about S3721
What is HCPCS code S3721?
S3721 is a HCPCS Level II code for prostate cancer antigen 3 (pca3) testing. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S3721?
The CMS HCPCS file marks S3721 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
Is S3721 still valid?
No. S3721 was terminated on December 31, 2015 and should not be used on new claims.